Arbloc CCB Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Per 5 mg/50 mg tab Amlodipine besilate 5 mg, losartan K 50 mg. Per 5 mg/100 mg tab Amlodipine besilate 5 mg, losartan K 100 mg

Indications/Uses

Mild to moderate HTN in case of inadequate control w/ monotherapy.

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Dosage/Direction for Use

Initially 1 tab daily, increased to 2 tab daily if necessary.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity.

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Arbloc CCB detailed prescribing information

Special Precautions

Amlodipine & losartan: Hepatic impairment, hypotension. Amlodipine: Patients w/ poor cardiac reserve, heart failure. Do not use in cardiogenic shock, patients who have recently suffered MI, or in acute unstable angina. Not for the treatment of chronic stable angina. Increased risk of developing heart failure in patients w/ severe aortic stenosis. Exacerbation of angina in sudden w/drawal. Discontinue use in ischaemic pain following administration. Losartan: Renal artery stenosis or renal impairment. Monitor serum K conc in elderly. Avoid concomitant use w/ K-sparing diuretics. Losartan: Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Dizziness, hypotension. Amlodipine: Flushing, headache, peripheral edema, tachycardia, palpitations; nausea & other GI disturbances, increased micturition frequency, lethargy, eye pain & mental depression; rashes (including erythema multiforme), fever, abnormalities in liver function, including cholestasis due to hyperplasia, myalgia, tremor, impotence. Losartan: Renal function impairment, hyperkalemia, myalgia; resp tract disorders, back pain, GI disturbances, fatigue & neutropenia.

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Drug Interactions

Amlodipine: Enhanced antihypertensive effects w/ β-blocker; aldesleukin & antipsychotics that can cause hypotension. May modify insulin & glucose responses when receiving antidiabetic treatment. Other CYP3A4 metabolized drugs eg, quinidine. Enzymes inducers (eg, carbamazepine, phenytoin, & rifampicin) & inhibitors (eg, cimetidine, erythromycin & HIV-PIs). Losartan: Potentiated antihypertensive effects w/ drugs or other agents that lower BP. Additive hyperkalemic effect w/ K supplements, K-sparing diuretics & other drugs causing hyperkalemia. Increased risk of renal impairment w/ NSAIDs. Drugs affecting CYP450 isoenzymes.

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Storage

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Description

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Action

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MIMS Class

Angiotensin II Antagonists / Calcium Antagonists

ATC Classification

C09DB06 - losartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.

Regulatory Classification

Presentation/Packing

Form

Arbloc CCB 5 mg/100 mg FC tab

Packing/Price

30's (P806.4/box)

Form

Arbloc CCB 5 mg/50 mg FC tab

Packing/Price

30's (P672/box)

Arbloc CCB

Manufacturer:

Cathay YSS

Distributor:

Cathay YSS